Granny and Tweety are riding through the desert in their wagon, to the tune of Oh! Susanna, when they are ambushed by Indians (who bear remarkable resemblance to Sylvester). They are forced to hole up in a fort, where Granny begins to shoot them down while Tweety counts (Ten Little Indians). On the tenth, one nearly takes Tweety, but is shot down just in time.
More attempts include an archer and a battering ram, both foiled. One archer almost drags Tweety out again ("Granny! Help! A Mohican got me!") but Granny surprises him with a bomb instead. The cats' attempts continue like this, all of them backfiring or being foiled.
Finally, Granny and Tweety disguise themselves as a fellow Indian, and lead the cats into the powder house. When one asks for a match, they kindly oblige, and the powder house explodes, causing all the cats to fall. "Oh my goodness!" Tweety comments, "It's raining putty tats!"
On the syndicated "Merrie Melodies" show, the part where an Indian cat drills a hole in the side of Tweety and Granny's fort shelter and preps to shoot them with a bow and arrow (only to get shot by a rifle and have his bottom half fall down like a loose pair of pants) was cut.
This cartoon, as a whole, has not been seen on American television since the early 1990s, due to ethnic stereotyping. Most overseas Cartoon Network and Boomerang stations, however have shown this cartoon uncut and uncensored.