The Lobe is Freakazoid's archenemy. He is a super genius with a very huge brain, though it is unknown how or why he has this huge brain, as his backstory and real name are never revealed at any point in the series' run. Despite his intellect, he has very low self-esteem, to the point that Freakazoid once easily stopped his schemes simply by pointing out the flaws in it. He also has henchmen, their names are Medulla and Oblongata. The Lobe also goes to the Washington Gardens a lot to eat.