The Lobe is Freakazoid's archenemy. He is a super genius with a very huge brain, though it is unknown how or why he has this huge brain, as his backstory and real name are never revealed at any point in the series' run. Despite his intellect, he has very low self-esteem, to the point that Freakazoid once easily stopped his schemes simply by pointing out the flaws in it. He also has henchmen, their names are Medulla and Oblongata. The Lobe also goes to the Washington Gardens a lot to eat.
Allies:Sergeant Mike Cosgrove • Roddy MacStew • Steff • Ingmar • Professor Jones • Hans • Professor Heiney • Joe Leahy • Expendable Lad • Freakazette • Foamy the Freakadog • Handman • Leonard Maltin • Henry Kissinger • Norm Abram Villains:Armondo Guitierrez • The Lobe • Cave Guy • Cobra Queen • Longhorn • Candle Jack • Kid Carrion • Waylon Jeepers • Vorn the Unspeakable • The Nerdator • Invisibo • Arms Akimbo • Milk Man • Mary Beth • Janos Ivnovels • Dr. Mystico Other characters in Freakazoid's segments:Emmitt Nervend • Bo-Ron • Fanboy • Deadpan • Hero Boy • Steven Spielberg • Paul Harvey • Lonnie Tallbutt Other segments:Lord Bravery • The Huntsman • The Lawn Gnomes • Toby Danger • Fatman and Boy Blubber