The title is a play on the 1954 Warner Brothers film The High and the Mighty starring John Wayne.
Foghorn lifts Dawg by the tail and slaps his rear end with a board so that the dog will chase him. The dog is in pursuit but reaches the end of his leash and is jerked to a stop. Foghorn then takes a beach ball, stuffs it in the dog's mouth, and punctures it, causing the dog to fly away. As Foghorn leaves he walks past a wooden tower with a sign that reads "Don't Look Up". Foghorn naturally looks up just in time to see the dog drop a watermelon on Foghorn's head. Foghorn contemplates "massive retaliation" against his nemesis. Daffy, a traveling salesman for the Ace Novelty Company of Walla Walla, Washington, has been watching their antics and seizes his opportunity. He enters with his traveling salesman suitcase of novelty joke items and offers to help Foghorn prank the dog by selling him a trick bone that is spring-loaded.
The prank works and Daffy then intervenes to help the dog get back at Foghorn with a gift-wrapped corn-on-the-cob that is connected to an electrical wire. Naturally, Foghorn wants to get back at the dog with an even bigger prank and Daffy sells him something called the Chattanooga Choo-Choo which ends up backfiring on Foghorn. To make up for the Chattanooga Choo-Choo, Daffy offers to sell Foghorn an elaborate prank called the Pipe Full Of Fun Kit Number 7, which Foghorn purchases. As Foghorn is setting up the trap, he sees the dog setting up the same trap to use against him, and they both realize that Daffy has been playing them against each other (and enriching himself in the process). Foghorn and the dog join forces to go after Daffy, who attempts to flee but is instead victimized by the Pipe Full Of Fun Kit, and Foghorn asks "You know, there might I say there just might be a market for bottled duck.".