Melissa Duck (in a model figure) is about to go to sleep, but she notices that her house is being haunted. She calls Daffy Duck to help her right away. Daffy quickly rushes over and checks the house. When he opens the oven, it is an arctic wasteland with small people living in an igloo. When he opens the refrigerator, and fire leaps out and burns him. When the cupboard is opened, there is a train heading straight towards him. He quickly slams it and thinks that the kitchen is a little crowed, he then sees Melissa (who had changed into a long flowy red halter dress) and quickly falls head over heels in love with her decides to snuggle with her to talk her about her situation. He soon finds out that she is possessed, so he gets a book and starts reading corny ghost jokes. The three ghosts that possessed Melissa jump out and the cartoon ends with the ghosts chasing Daffy down the street with Melissa calling out (in a southern accent) "Y'all come back now ya hear!" as the cartoon ends.
When The Duxorcist aired as an individual cartoon on ABC's The Bugs Bunny and Tweety Show, Daffy's line after he pushes the possessed female duck (Melissa) off him ("Oh no, not another schizophrenic dame. Hey, Sybil, any more like you in the family? Can you send back that older sister of yours?") was replaced with the scene of Daffy saying, "I don't know my own strength!" (which was cut from the scene of Daffy kissing Melissa and triggering her possession) due to a Standards and Practices rule stating that mental illnesses could not be mocked or even mentioned.