The Comic Center of Pasadena, more commonly referred to as "the comic book store", was a place where the guys frequently visited to buy their comic books and hang out, until it was burnt down in an accident revealed in the 7th season finale, but was later rebuilt, using Howard's mother's furniture, much to Howard's chagrin and dismay. The store is owned by Stuart Bloom. The store's name has only appeared twice on the show on its door, and has only been mentioned out loud once in "The Comic Book Store Regeneration".
The store used to have a website at http://www.thecomiccenter.com (in reality, the domain name is registered to Warner Brothers), but it has gone offline since 2011. Similarly, its Facebook page has gone idle since 2011 too.
The store first appeared in "The Hofstadter Isotope" where Penny follows the guys to the store to buy a gift for her nephew. Stuart recommends her a comic book for the gift. She sees Stuart has drawn a portrait of her, which he exchanges for her number.
In "The Creepy Candy Coating Corollary", the store hosted The Mystic Warlords of Ka'a Tournament.
The store has hosted a Stan Lee signing thanks to Stuart's connections in "The Excelsior Acquisition". The logo of the store is shown when the guys are lined up outside waiting to meet Stan Lee, wherein the sign is visible; the only time the outside of the store was shown.
In "The Wheaton Recurrence" Stuart wins a bet and makes the guys dress up like DC super heroines.
Stuart also hosts a costume party on New Year's Eve which the gang won for the best Justice League of America team in "The Justice League Recombination".
Raj hosts a Scavenger Hunt in "The Scavenger Vortex" which first puzzle is the Comic Book Store in a puzzle.
The store suffered a huge fire and is gutted in the Season 7 finale "The Status Quo Combustion" due to Stuart's hotplate. Stuart claims the insurance company thinks he did it for money. Also the police and his therapist. He did not get enough money from the insurance company to reopen so Debbie Wolowitz gave him the rest of the money. The store was reopened in "The Comic Book Store Regeneration".
Stuart lived in the back of the store when necessary.