Scooby-Doo! Music of the Vampire is a 2012 direct-to-DVD animated musical comedy horror film, and the seventeenth entry in the direct-to-video series of Scooby-Doo films. This installment is notable for being the first of the films to be a musical. The film was released to rent through Amazon Video and iTunes on December 22, 2011. It was released on DVD and Blu-ray on March 13, 2012. It premiered on Cartoon Network on March 3, 2012.
The film begins with an introductory song by Tulie, a bayou dweller, who tells the story of Valdronya and the Mystery Inc. gang. After solving the mystery of a Cockroach Monster that terrorized a factory, Fred, Daphne, Velma, Shaggy, and Scooby decide to take a well-deserved vacation. Velma drives everyone to Chauve Sourie Ville, a small town hosting a vampire festival called "Vampire Palooza." They meet Lita Rutland, the festival organizer, who explains that tourism is down and the festival is losing funds. They also meet their host, Vincent Van Helsing, who runs a vampire museum and is an aspiring author, although his books are not selling. Mayor Jasper Poubelle, an anti-vampire agitator, is also stirring up trouble by protesting the festival. Mr. Van Helsing takes the gang back to his museum and shows them various jewelry and a glass-faced casket containing the inert body of Valdronya, a centuries-old vampire.
The Gang and Van Helsing attend a performance by a troupe of vampire actors. The troupe leader Bram, who catches the eye of Daphne, announces the group will perform a vampire resurrection ritual. To everyone's surprise, their incantation proves successful, and the resurrected Vadronya appears on the stage before flying away. The gang discovers the jewels missing back at the museum, and the body is gone, although the tomb is still sealed. Out on the festival grounds, they find Lita Rutland wants to profit from the publicity of the vampire appearance. She tells a phony story about being attacked that gets on the news. Mayor Poubelle also gets a media exposure benefit for his anti-vampire crusade. They check out the trailer of his organization and discover he plans to run for Mayor and is using the vampire story to increase his notoriety. On the way back, they are attacked by Valdronya. He clings to the top of the Mystery Machine and reaches in through the skylight. Daphne tears off a piece of fabric from his sleeve, and Velma forces him off the car by running through a very low tunnel.
That night, Shaggy and Scooby are attacked by Valdronya and chased into the swamp, where Shaggy thinks he's been bitten and will turn into a vampire. They meet Tulie, who reveals he invented a pair of hover shoes, but the plans were stolen by vampires, and he was forced to flee into the swamp. Meanwhile, Fred, Daphne, and Velma discover the fabric from Vadronya's costume is from modern material. Van Helsing, however, says the clothing has been changed over the years, but the body is still the original vampire. Daphne decides to question the troupe and meets with Bram. However, when she turns down his offers of affection, with a promise of immortality, he kidnaps her to become the bride of Valdronya.
Daphne alerts Fred via text message, and Fred, Velma, and Van Helsing travel into the swamp to stop the marriage ceremony. On their way, Van Helsing is pulled from the ship and disappears; when Fred and Velma investigate, they instead find Shaggy and Scooby, where Velma proves to Shaggy that he is not turning into a vampire as it was just a splinter on his neck, not a bite mark. The actors tie Daphne by the hands between two trees, and they tell her they expect to be rewarded with immortality if they give her to Valdronya as his bride. Instead, the monster appears to claim his bride, and with a swirl of green mist, he sends the actors to sleep, telling them that they will be immortal when they awake. Daphne also succumbs to the mist, and in a trance, she agrees to the wedding. Valdronya arrives, but Shaggy and Scooby distract him. In the ensuing chase, Valdronya's costume is blown away by Scooby and Shaggy's airboat's propeller, and the vampire is then captured by Fred.
Valdronya is unmasked and revealed to be Van Helsing. He wanted to stage a vampire wedding to create his own new tourist attraction and sell more books. He used the stolen rocket shoes, knockout gas, and holographic projections to create the monster effects. The hands that dragged him away were just a machine he prepared in advance. He created a fake story about the vampire's clothing when he thought the gang was getting close to him. The actors were duped into thinking he was a real vampire who could grant them immortality, so they helped him. The Sheriff arrests Van Helsing and the actors. Bram makes an appeal to go on a date with Daphne after he gets out of prison. She coldly rejects the idea because she never dates actors. The gang then goes on another vacation where they hope not to run into any more monsters or mysteries.