In the beginning, a cockroach named Skippy is seen getting inside of Roach Coach's room. While Roach Coach is seen watching people through a window, he gets quite angry because of all the noise outside. After a while, Roach Coach turns around seeking Skippy. Skippy told him info about thePowerpuffGirls, which escalated in Roach Coach inviting all of the cockroaches in his home to gather around.
Roach Coach made his statement to his cockroaches that Powerpuff Girls are disgusted by them and that they should smash the girls and take over the world. Roach Coach then released all of his cockroaches all over the world, letting them destroy the world. Eventually the Mayor calls the girls after Bubbles unintentionally hangs up on him repeatedly. Grossed out, the girls go to the city, seeking what is going on.
Eventually, the girls caught all the roaches inside of a huge jar, which escalated in Roach Coach using his whistle, which made the cockroaches escape and create a giant cockroach witch inside is Roach Coach. In the end, they have a battle against each other. As they destroyed Roach Coach, finding a cockroach inside of Roach Coach, capturing only him inside of a jar.
Production on this episode began long before the series premiered.
This episode was supposed to be the first one to air because it was produced first, but because Cartoon Network often airs episodes out of production order, it aired second.
When we first see the tall building on the outside, the red window is one level down from the top, but when we view the building the second time when Roach Coach is yelling, the window is on the top level.
Despite having his robot body destroyed, Roach Coach makes several cameos in later episodes.
Ms. Bellum's first name is revealed to be Sara, which her full name is a pun for "cerebellum" (Latin for "little brain"), which part of the brain that plays a vital role in virtually all physical movement.
As mentioned above, this episode was meant to be the series premiere, but it was actually "Monkey See, Doggie Do" that aired first, as mentioned above. This episode was held off until the following week as the first part of the second episode.
The moral of this episode is the same as "Substitute Creature": don't judge something by their looks, unless they are as bad inside as outside.
Season 1:Monkey See, Doggie Do • Mommy Fearest • Insect Inside • Powerpuff Bluff • Octi Evil • Geshundfight • Buttercrush • Fuzzy Logic • Boogie Frights • Abracadaver • Telephonies • Tough Love • Major Competition • Mr. Mojo's Rising • Paste Makes Waste • Ice Sore • Bubblevicious • The Bare Facts • Cat Man Do • Impeach Fuzz • Just Another Manic Mojo • Mime for a Change • The Rowdyruff Boys • Uh Oh Dynamo Season 2:Stuck Up, Up and Away • Schoolhouse Rocked • Collect Her • Supper Villain • Birthday Bash • Too Pooped to Puff • Beat Your Greens • Down n' Dirty • Dream Scheme • You Snooze You Lose • Slave the Day • Los Dos Mojos • A Very Special Blossom • Daylight Savings • Mo Job • Pet Feud • Imaginary Fiend • Cootie Gras • The Powerpuff Girls Best Rainy Day Adventure Ever • Just Desserts • Twisted Sister • Cover Up • Speed Demon • Mojo Jonesin • Something's a Ms. • Slumbering with the Enemy Season 3:Fallen Arches • The Mane Event • Town and Out • Child Fearing • Criss Cross Crisis • Bubblevision • Bought and Scold • Gettin' Twiggy With It • Cop Out • Three Girls and a Monster • Monkey See, Doggy Two • Jewel of the Aisle • Super Zeroes • Candy Is Dandy • Catastrophe • Hot Air Buffoon • Ploys R' Us • The Headsucker's Moxy • Equal Fights • Powerprof. • Moral Decay • Meet the Beat Alls • Helter Shelter • Power Lunch Season 4:Film Flam • All Chalked Up • Get Back Jojo • Him Diddle Riddle • Super Friends • Members Only • Nano of the North • Stray Bullet • Forced Kin • Knock It Off Season 5:Keen on Keane • Not So Awesome Blossom • Power-Noia • Monstra-City • Shut the Pup Up • Toast of the Town • Divide and Conquer • Burglar Alarmed • Shotgun Wedding • Save Mojo • Substitute Creature • The Boys Are Back in Town • See Me, Feel Me, Gnomey • Pee Pee G's • Boy Toys • Seed No Evil • The City of Clipsville • Lying Around the House • Bubble Boy • A Documentary • Girls Gone Mild • Curses • Bang for Your Buck • Silent Treatment • Sweet 'n' Sour Season 6:Prime Mates • Coupe D'Etat • Makes Zen to Me • Say Uncle • Reeking Havoc • Live & Let Dynamo • Mo' Linguish • Oops, I Did It Again • A Made Up Story • Little Miss Interprets • Night Mayor • Custody Battle • The City of Nutsville • Aspirations • That's Not My Baby • Simian Says • Sun Scream • The City of Frownsville • West in Pieces • Crazy Mixed Up Puffs • Mizzen in Action • Roughing It Up • What's the Big Idea? • Nuthin' Special • Neighbor Hood • I See a Funny Cartoon in Your Future • Octi-Gone Reboot:
