The Road Runner (Burnius-Roadibus) races right to left along a stretch of desert highway, with the Coyote (Famishus-Famishus) behind him. The Road Runner stops and steps aside. The Coyote passes him and stops in a cloud of dust. The Road Runner then zips into the distance with the force lifting the ribbon of pavement off the ground in his wake. Wile E. lowers his expectations (and his mouth) and thinks of a new scheme.
The gags are as follows:
The Coyote, on a cliff, drops a washtub on the Road Runner on the road below, jumps on it and puts a stick of dynamite underneath it. The Road Runner zips up to him. The Coyote goes under the washtub to investigate why the bird isn't there and the dynamite blows up, encasing the Coyote in a tube made from the washtub.
The Coyote hides around a corner to bash the Road Runner with a sledgehammer. But the hammer falls off and the stick bashes the Coyote and chases him into the distance.
Birdseed is place on some railroad tracks but a train runs down the Coyote before he can get off the runway.
Attached to a green balloon, the Coyote carrying a harpoon jumps off a cliff, tied to a rope. He misses the Road Runner, but the force carries him into a storm cloud. The harpoon attracts lightning which zaps the Coyote (and in turn, dissolving the rope, causing him to fall).
A bundle of dynamite is rolled beneath a short underpass. But gravity carries the bundle back to the Coyote's hiding spot and one push of the plunger blows him up.
Using a rope and a pulley, the Coyote raises a baby grand piano high above the road. As the Road Runner passes, the Coyote lets go of the rope, which sticks in the pulley. The Coyote jumps on top of the piano, which loosens the rope and causes the piano - and the Coyote - to drop to the ground. Dazed, the Coyote opens his mouth to reveal that the piano keys are now his teeth; he plays "Taps" on them briefly before passing out.
An elaborate Rube Goldberg -type gag ends the cartoon. The Coyote uses a tiny slingshot to knock loose a stick holding up a watering can suspended on a wooden yardarm. The can tips and water pours onto a plant which has a wooden match attached to it. The plant grows and the match strikes against a rock and lights a stick of dynamite. On top of the dynamite is a boot with a brick in it. The blast sends the boot ontop of a teeter board, which rises and releases a mouse in a cage at the other end. The mouse runs to grab a piece of cheese on a scale. A weight on the other end of the scale falls, pulling the trigger on a rifle attached to a cliff. A bullet from the rifle ricochets off two metal bullseyes and knocks down an upright cannon. The wick on the cannon is lit by a nearby candle, which fires a ball that goes through two funnels and plummets on top of the unsuspecting coyote. After the coyote is bashed into the ground, 'The End' appears on the cannonball as the cartoon irises out.
"That's all Folks!"
The title is a pun on the title Hook, Line and Sinker.
The theme to the situation comedy television show Dennis the Menace composed by William Loose and Seely, and originally in the Hi-Q library, is not in this cartoon. A variant also written by the two for Hi-Q is used instead.
Most of the background music was composed by Philip Green for the EMI Photoplay library and were give GR designations by that library. Some of the cues heard:
GR-463 The Artful Dodger (Green) in the first gag.
L-78 Comedy Underscore (Spencer Moore) and GR-255 Puppetry Comedy (Green) in the second gag.
GR-459 Dawn in Birdland and GR-97 By Jiminy! It's Jumbo Bridge No. 1 (both by Green) in the third gag.
GR-256 Toyland Burglar (Green) at the start and end of the fourth gag.
TC-303 Zany Comedy (Loose and Seely) in the sixth gag. This piece of music was also heard in many early Yogi Bear cartoons.
L-82 Comedy Underscore (Moore) at the start of the seventh gag.
VHS - Road Runner vs. Wile E. Coyote: The Classic Chase