In the beginning, Frank is lazy, gluttonous, unhealthy, illogical, and sarcastic. These traits come from suffering depression over the death of his wife, Maggie whom Frank did seem to deeply love. However, it wasn't until after Frank became a laughingstock when he accidentally puked on Shane's science and physical education teacher, Mrs. Boyd that Frank started overeating and foregoing basic hygiene. It is the death of his wife and ridicule that Frank gets from almost everyone around him (except for his family) that causes Frank to eat junk food and not take care of himself in order to cope with the tragedies in his life. Yet, it is shown Frank never considers the thought of dying as he knows he has to care his daughter, Shane whom he deeply loves.
Because Frank loves his daughter more than anything, Frank does care about her, but because his body is under the control of Mayor Phlegmming, he selfishly puts his needs above hers where he is barely able to keep any promises with her. However, Frank does care about Shane's happiness and well-being where he attempted to convince Mrs. Boyd to lift her restraining order so he could attend her school's hiking trip with her. In addition, Frank did look uncomfortable when his brother, Bob announced he'd planned to have Shane leave his home at age sixteen if anything happened him.
In spite of his flaws, Frank is a good man where he does seem to regret his lifestyle choices that he makes when under Phlegmming's influence. He also regretted how his decision to eat a polluted oyster affected not only himself, but also Mrs. Boyd and Shane. And because of Frank doing barely little to change his ways due to suffering from depression and not getting enough help, most likely due to being under Phlegmming's influence, his relationship with Shane grew estranged as a result.
However, after being saved by Osmosis Jones from being killed by Thrax, Frank grew more responsible and careful with not only himself, but his lifestyle choices. In addition, Frank shed all of his negative qualities and moved on from his wife's death and the mockery he'd received; thus, allowing him to become a more outgoing, reasonable, and healthy man while reconciling with Shane and developing a better relationship with her.
Location Inside[]
Downtown Frank[]
The organs and bones inside of Frank’s body resemble that of a large city.
Role in the film[]
Frank lost his wife to some unknown disease, and he was left to take care of Shane. His life began to spiral out of control after an incident at Shane's science fair. After eating raw oysters from a display, Ozzy discovers a virus on one of them and induces Frank to throw up. Unfortunately it was on Shane's science teacher. Frank became the laughing stock of the town, and was fired from his job at a pea soup factory. His brother Bob hooked him up with a job at the zoo, where he has worked ever since. He accidentally infects himself with a virus after eating a boiled egg that was covered in chimp saliva and mud. As a result, he nearly dies from the fever that it brings. After his near death experience, Frank decides to take better care of himself, so he can be there for Shane.
Despite trying to be healthy after the movie, Frank regained most of his weight even becoming much fatter than in the movie (assuming this isn't an alternate continuity). His only role in the show was getting bitten by a mosquito which sucked Ozzy, Drix and a germ they were fighting out of him and sends them in to the body of Hector Cruz. He isn't seen again until he makes a small cameo in "The Globfather" where he appears as one of the citizens at Rusty's Ridetropolis.
Due to suffering from depression, it is possible Frank never considered seeing a therapist because of the incident at Shane's science fair made him a laughingstock.
