Hungry cat Sylvester sees that Tweety is in his nest, which sits on a tree atop a dog pound, which is the home to numerous bulldogs. Sylvester tries different methods for getting up the tree, including disguising himself as a dog, but none of them are working. Eventually he disguises himself as a skunk, which almost works until Pepé (who mistakes him for a female skunk) starts flirting with him.
This is the only appearance of Pepé Le Pew (a Chuck Jones character) in a Friz Freleng cartoon. Later the same year, Tweety would appear for the only time in a Chuck Jones cartoon; "No Barking".
Similar in concept to "Ain't She Tweet", this cartoon also centers around Sylvester trying to catch Tweety who is surrounded by bulldogs, except that here Granny doesn't appear and Tweety is not a pet.