New episodes aired same-day on Cartoon Network and Boomerang. On March 23, 2017, Bunnicula returned after a year-long hiatus when five new episodes aired unannounced on Boomerang in a graveyard slot. It returned again on November 6, 2017. Eventually, the series was picked up for a second and third season. Bunnicula Season 2 is back on Boomerang Channel on March 8, 2018.
On January 18, 2018, it was announced that Bunnicula has had its last recording session, meaning that the show will conclude after its third season.
Chester (voiced by Sean Astin): Mina's pet Siamese cat. He is often exasperated with Bunnicula and terrified of the monsters and supernatural phenomena that happens around him and his friends. Deep down, Chester is jealous of Bunnicula. In the books, Chester is an eccentric Orange tabby whose wild suspicions of occult phenomena constantly exasperate Harold.
Bunnicula (voiced by Chris Kattan): The titular character of the show, Bunnicula is a vampire rabbit, and was once the pet of Count Dracula. He is very different from the original version of the character who appears in the books. As it was said by Chester, Bunnicula was found in a locked chamber in the cellar of the apartment complex that Mina, Harold, and Chester now live in. Also, he is shown to have a few vampire traits such as hiding from sunlight, sleeping in a casket, flying with bat wings, and draining juice from vegetables with his fangs. It has been seen that he cannot talk except for a few words (although Harold seems to understand him just fine). He cares for Mina a great deal but tends to cause mischief that yields supernatural consequences. Bunnicula sucks juices from vegetables (just like in the book) but different kinds of vegetables cause some kind of reaction in Bunnicula (carrots enhance his vision, sugar beets make him hyperactive and speedy, squashes enlarge his feet, onions make him cry powerful jet streams of tears, garlic turns him into a skeleton bunny, ghost peppers make him breath out a fire demon, rutabagas give him telekinesis, turnips turn the house upside-down, wasabi makes him spontaneously combust, leeks give him spider legs, eggplants turn him into a huge and hideous three-eyed monster rabbit, babby carrots make him shrink, rotten yams make him invisible, mandrake roots makes him taller with a more humanoid body, horseradish turns him into a horse, etc.). In the books, it was unclear whether or not Bunnicula had vampiric powers although he was somehow able to get in and out of his cage without opening the door. Unlike his Ruby-Spears incarnation, Bunnicula's ears turn into bat wings to fly. He also speaks very limited English on rare occasion.
Harold (voiced by Brian Kimmet): Mina's pet dog. He loves his friends Chester and Bunnicula, and their owner, Mina, but isn't the sharpest tool in the shed and appears to be a short-haired, brown mutt. In the books, Harold is a ponderous, thoughtful character, forced to put up with the eccentricities of Chester and the new rabbit. In the books Harold is intelligent and he resembles an Old English Sheepdog, though he claims to have Russian Wolf Hound in him as well.
Mina Monroe (voiced by Kari Wahlgren): Harold, Chester, and Bunnicula's 13 year old punk owner who just moved to New Orleans, Louisiana from Middle America with her father. It was seen in the opening that she was the one who freed Bunnicula from his prison in the cellar with a key that was given to her by her Aunt Marie. Aunt Marie left an apartment to Mina and her father. Mina's mother is never seen or mentioned. In the books Chester, Harold, Bunnicula and Howie are owned by Robert, Ann, Pete, and Toby Monroe. In the books Mina's name is Toby.
Fluffy (voiced by Sumalee Montano): A Doberman Pinscher who is a vampire hunter that wants to kill Bunnicula at any cost.
Arthur Monroe (voiced by Chris Kattan): Mina's father who moves with his daughter to New Orleans from Middle America after inheriting an apartment from Aunt Marie. He appears to be mentally unstable, as in “My Imaginary Fiend” he is seen talking to air, and in “Family Portrait” he throws a princess themed 13th birthday party for Mina. His wife isn't seen or mentioned in the series. In the books Arthur's name is Robert.
Marsha (voiced by Monie Mon): Mina’s cautious and shy best friend, who serves as a foil to the outgoing Mina. Marsha is extremely unlucky, and often only human to notice supernatural activity.
Becky (voiced by Kate Higgins): Mina’s other best friend. Becky is very monotone and sarcastic, acting like the stereotypical teenage girl.
Scott Dingleman (voiced by Scott Menville): Mina's love interest who shares many of her interests. Bunnicula, Chester, and Harold accidentally erased Scott's memories and tried to take advantage of him until they realized how much Mina missed Scott, and so restored his memory. For some reason, Scott can now understand them but chose to keep it a secret
Madame Polodouri (voiced by Grey Griffin): The owner of a shop containing many supernatural objects. Madame Polodouri often has dangerous items on display, though her knowledge of them depends; in “Walking Fish” she refuses to sell a harmonica that revives all the dead fish in New Orleans as zombies, yet unknowingly sells the Haunted Portrait of Miserio to Arthur in “Family Portrait”. Madame Polodouri doesn't like children or pets in her shop.
Patches the Weredude (voiced by Eric Bauza): A laidback, fun-loving weredude. Patches often forgets he is a weredude, and acts like a cat even in human form. Patches moved into the Orlok in “Revenge of the Return of the Curse of the Weredude”.
Lugosi (voiced by Richard Steven Horvitz): A deformed and insane guinea pig obsessed with serving Bunnicula, but his way of doing so makes him an enemy. He is later adopted by Marsha, who he declares his new master. Lugosi is now an ally of Bunnicula.
Chris Katten - Bunnicula, Man Brushing Teeth, Mina's Dad
Brain Kimment - Harold, 20's Male Gangster, Dracula, Gamer 2, Male Cat 2, Male TV Actor, Man in Dining Room, Officer Bacon, Plant, Raccoon 1, Zombie Vegetable, Hideous Thing
Sean Astin - Chester, Caged Bird, Garlic Man, Nutty Pete, Officer Ham
Kari Wahlgren - Mina, 20's Female Gangster, Bunnicula's Bride, Cool Cat, Customer, Duck 1, Female Cat 1, Female Cat 2, Female Cat 3, Lady in Flashback, Female TV Actor, Elvira
Eric Bauza - Gamer 1, Gamer 3, Patches
Suzanna Blakeslee - Renee Accoutrement
Yvette Nicole Brown - Ms. Varney
Luenell - Ted's Wife
Grey DeLisle-Griffin - Lady on TV, Madame Polodouri
In Canada, the series started airing on Teletoon on April 2, 2016. The series premiered on Boomerang on May 2, 2016, in the United Kingdom and Ireland. The series premiered on Boomerang on July 18, 2016, in Australia and New Zealand.
Common Sense Media gave the series three stars out of five.
"Night of the Vegetable", a 2-disc DVD set featuring the first 20 episodes of first season, was released on June 27, 2017.